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NewGeneris Project: Newborns and Genotoxic exposure risks

NewGeneris is an Integrated Project conducted within the European Union's 6th Framework Programme, priority area Food Quality and Safety. Its objective is to investigate the role of prenatal and early-life exposure to genotoxic chemicals present in food and the environment in the development of childhood cancer and immune disorders.

During recent decades there has been an accelerating increase of the incidence of childhood cancers, especially leukemias. A world-wide increase is also observed in the prevalence among children of immune diseases, including asthma, allergic rhinoconjunctivitis and atopic eczema/dermatitis.

There may be biological and etiological links between the onset of childhood cancer and immunological disorders. Among such possible links is exposure to genotoxic-carcinogens (i.e. carcinogenic chemicals capable of causing damage to the genetic material of cells) with associated immunotoxic properties, present in the environment, including food. NewGeneris is examining the possible role of exposure to such chemicals during pregnancy in the induction of increased risk of cancer and immune disorders in childhood. The relevance, for such risks, of analogous exposures of the fathers at the time of conception, as well as of the children themselves during their very early lifetime, is also being investigated.

Research approach

The main research tool used is biomarkers, i.e. chemical or cellular components of human fluids or tissues, which reflect exposure to, early effects of, or susceptibility to toxic chemicals. In NewGeneris, biomarkers are measured mostly in samples of maternal and umbilical cord blood collected from groups of mother-child pairs (birth cohorts) and stored in large collections ( biobanks ). Information regarding the dietary exposures of the mothers, the fathers and the children themselves during early life, is extracted from validated questionnaires. The combined analysis of data on exposure, biomarkers and information on the health status of the children as they grow older will be utilised to evaluate the role of early-life exposures in the causation of disease, to identify genetic traits which lead to increased individual susceptibility to disease and to evaluate their public health implications of such findings.

Towards a European birth mega-cohort

comeThe biological samples available to NewGeneris  from already existing biobanks in 5 different European regions, while 3 new biobanks will also be created. Between them, these biobanks represent a total of around 300,000 mother-child pairs, constituting in effect a virtual European birth mega-cohort with subjects coming from regions with a wide diversity of environmental conditions and dietary and lifestyle habits. This makes NewGeneris one of the largest studies of its kind ever conducted and provides it with a unique potential to discern the role of food-borne chemicals in the etiology of childhood cancer and immune disease.

Social relevance: Safer food and environment to protect children

With its emphasis on health risks for newborn children associated with in utero exposure to chemicals as a consequence of their dietary intake by the mother, NewGeneris provides a novel perspective on the issue of food safety. From the project/s results, policy measures may be derived to improve food quality by appropriate selection of raw materials and use of appropriate food production methods. The ultimate aim is to contribute to the protection of child health through the formulation of improved health policies, more effective food regulations specially targeted at children and better food quality.

NewGeneris also serves the objective of the EU Sixth Environment Action Programme to achieve a quality of the environment where the levels of man-made contaminants do not give rise to significant impacts on or risks to human health, by contributing to the research effort to develop science-based risk assessment into a tool for improved chemical and food safety.

      
Highlights

NewGeneris Publication, in EHP Oct 2012
Acrylamide and pregnant women Mothers with high dietary intake of acrylamide during pregnancy have lower birth weight babies

 For NewGeneris partners: Instructions on use of internal website section (log in first)

   

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NewGeneris: Newborns and Genotoxic Exposure Risks
5 years of progress
Download Brochure
(For printing, select "Fit to Page")

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NewGeneris Final Annual Meeting 
Maastricht, Netherlands
17 January 2011

http://newgeneris2011.org


NewGeneris Final Workshop
Maastricht, Netherlands, 18 January 2011
Preliminary Workshop Programme

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European Commission
RTD Food, Health and Well-Being Newsletter
Issue July 2010

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EEMS 40th Meeting ,Oslo, 15-18 September 2010 

Society for Free Radical Research Meeting ,Oslo, 12-15 September

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Food for the 21st Century: The Impact of EU Research upon European Food and Safety
Brussels, 8 July 2010


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NewGeneris at DG Research meeting for Communication Managers
Brussels, 23-24 March 2010

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EFSA: Overview of food acrylamide levels in 2008

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NewGeneris at the Fifth Ministrial Conference on Environment and Health,
Parma, 10-12 March, 2010

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PARMA DECLARATION ON ENVIRONMENT AND HEALTH
Parma, 10-12 March, 2010
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NewGeneris on DG Research website:
European Research Headlines


and on CORDIS website  
April 2010
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HENVINET: Cause-Effect Diagrams
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NewGeneris Newsletter Issue 4-5
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AUTOMATION OF THE HUMAN MICRONUCEUS CYTOME ASSAY FOR HIGH THROUGHPUT ANALYSIS
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NewGeneris Workshop "New approaches in epidemiological research on environment and child health"
Heraklion, Crete, 5 February 2010
(within the frame of NewGeneris 4th Annual Consortium Meeting)

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Comparative Toxicogenomics the Database (CTD)
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The Exposome: A Powerful Approach for Evaluating Environmental Exposures and Their Influences on Human Disease
Washington, 25-26/02/2010
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NewGeneris 4th Annual Consortium Meeting
Crete, Heraklion, 3-4 February 2010

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Fifth Ministerial Conference on Environment and Health
"Protecting children's health in a changing environment"
Parma, Italy, 10-12 March 2010

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NewGeneris project at the "European Food Science Day" organized by CommNet (Communication Managers in EU-funded food projects)
Brussels, 18/11/2009

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HENVINET: Online Networking in Environment and Health
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NewGeneris in ICEM2009
Florence, Italy, 20-25 August 2009

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Newgeneris PBM &
Discussion on Health Risk Assessment 
2-3 November 2009, Heidelberg, Germany

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Comet Assay training DVD and 'Lectures Protocols Info' are available online

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NewGeneris Newsletter Issue 2-3

NewGeneris Newsletter Issue 1



 
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 NewGeneris information material

 

 

 

 

 

 

 

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